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Saturday, November 13, 2010

KERLEY LINES

Kerley’s A lines (arrows)

Kerley’s B lines (white arrowheads)

Kerley’s C lines (black arrowheads)



Kerley lines are a sign seen on chest radiographs with interstitial pulmonary edema. They are thin linear pulmonary opacities caused by fluid or cellular infiltration into the interstitium of the lungs. They are named after Peter Kerley.


Types

Kerley A lines
Longer (at least 2cm)
Unbranching lines
Coursing diagonally from the periphery toward the hila in the inner half of the lungs. Caused by distension of anastomotic channels between peripheral and central lymphatics of the lungs.
Kerley A lines are less commonly seen than Kerley B lines.
Kerley A lines are never seen without Kerley B or C lines also present.
Kerley B lines
These are short parallel lines at the lung periphery.
These lines represent interlobular septa
Usually less than 1 cm in length
Parallel to one another at right angles to the pleura.
They are located peripherally in contact with the pleura, but are generally absent along fissural surfaces.
They may be seen in any zone but are most frequently observed at the lung bases at the costophrenic angles on the PA radiograph, and in the substernal region on lateral radiographs.
Kerley B lines are seen in Congestive Heart Failure (CHF) and Interstitial Lung Diseases (ILD).
Kerley C lines
Least commonly seen of the Kerley lines.
Short, fine lines throughout the lungs, with a reticular appearance leading to spider web appearance.
They may represent thickening of anastomotic lymphatics or superimposition of many Kerley B line.

Wednesday, November 10, 2010

Peptide analogs

Peptide analogs

Overview of insulin secretion

Incretin mimetics

Incretins are insulin secretagogues. The two main candidate molecules that fulfill criteria for being an incretin are Glucagon-like peptide-1 (GLP-1) and Gastric inhibitory peptide (aka glucose-dependent Insulinotropic peptide or GIP). Both GLP-1 and GIP are rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4).

Glucagon-like peptide (GLP) analogs and agonists

GLP agonists bind to a membrane GLP receptor.[2] As a consequence of this, insulin release from the pancreatic beta cells is increased. Endogenous GLP has a half life of only a few minutes; thus an analogue of GLP would not be practical.

These agents may also cause a decrease in gastric motility, responsible for the common side effect of nausea, and is probably the mechanism by which weight loss occurs.

Gastric inhibitory peptide (GIP) analogs

  • None are FDA approved

DPP-4 inhibitors

Dipeptidyl peptidase-4 (DPP-4) inhibitors increase blood concentration of the incretin GLP-1 (glucagon-like peptide-1) by inhibiting its degradation by dipeptidyl peptidase-4 (DPP-4).

Typical reductions in A1C values are 0.5-1.0%.

Examples are:

Amylin analogues

Amylin agonist analogues slow gastric emptying and suppress glucagon. They have all the incretins actions except stimulation of insulin secretion. As of 2007, pramlintide is the only clinically available amylin analogue. Like insulin, it is administered by subcutaneous injection. The most frequent and severe adverse effect of pramlintide is nausea, which occurs mostly at the beginning of treatment and gradually reduces. Typical reductions in A1C values are 0.5-1.0%.

Tuesday, November 2, 2010

ACUTE PANCREATITIS

Pancreatitis (acute): causes GET SMASHED:
Gallstones
Ethanol
Trauma
Steroids
Mumps
Autoimmune (PAN)
Scorpion stings
Hyperlipidemia/ Hypercalcemia
ERCP
Drugs (including azathioprine and diuretics)

Pancreatitis: criteria PANCREAS:
PaO2 below 8
Age >55
Neutrophils: WCC >15
Calcium below 2
Renal: Urea >16
Enzymes: LDH >600; AST >200
Albumin below 32
Sugar: Glucose >10 (unless diabetic patient)

Pancreatitis: Ranson criteria for pancreatitis at admission LEGAL:
Leukocytes > 16.000
Enzyme AST > 250
Glucose > 200
Age > 55
LDH > 350

Pancreatitis: Ranson criteria for pancreatitis: initial 48 hours "C & HOBBS" (Calvin and Hobbes):
Calcium < 8
Hct drop > 10%
Oxygen < 60 mm
BUN > 5
Base deficit > 4
Sequestration of fluid > 6L